Jack began his research career as a whole-cell electrophysiologist before a growing interest in imaging techniques led him into confocal then 2-photon microscopy in the late 1990s. The Waters lab has made extensive use of imaging techniques, particularly 2-photon microscopy, since its inception in 2005 and began using 3-photon microscopy as the first laser systems suitable for 3-photon excitation became commercially available in late 2016.
Jack has taught microscopy throughout his faculty career, including 10 years as a director of the 'Imaging structure and function in the nervous system' summer course at Cold Spring Harbor Laboratory. Jack started 3photon.org to facilitate dissemination of information on the fast-growing field of 3-photon microscopy.
Jack is currently an Associate Investigator at the Allen Institute for Brain Science in Seattle, WA.